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Pharmacodynamic Effects and Duration Despite measurable plasma clearance, pharmacodynamic effects extend well beyond plasma half-life[20]: Weight loss effects continue throughout treatment with no plateau observed within 48-week study periods Glycemic improvements persist between weekly doses with stable glucose control Appetite suppression effects remain consistent throughout dosing intervals Tissue receptor occupancy likely exceeds plasma peptide concentrations This disconnect between pharmacokinetics and pharmacodynamics suggests prolonged receptor engagement, tissue depot effects, or persistent downstream signaling cascade activation

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GHK-Cu stimulates the production of dermatan sulfate and glycosaminoglycans that hydrate and plump the dermal matrix, measurably improving skin thickness and density over treatment courses

The importance of PDGF in vessel function was demonstrated by lethality of mice lacking components of the PDGF-B/PDGFR pathway, displaying vessel leakage and micro-hemorrhage [142]